Pack your bags, the girls are going south! The son of Satan in a bid to assume control of Hell has sent an emissary to earth with a wedding invitation for Vampirella. Detective Sara Pezinni thinks she knows evil, but when a little girl carrying a severed head starts a bloody rampage in a New York hospital her definition is about to be redefined. Drawn together by fate and circumstance Vampirella and Witchblade stand on the front lines of a battle for dominion over hell with Drakulon hanging in the balance.