The mysterious and deadly Bloodwing is killing all the Vampirellas throughout the fabric of reality-but who is he, and why is he doing this? It's up to Vampirella to learn the secrets of Bloodwing and stop him.

Thanks to the Book of Prophecy (in a very unexpected way), Vampirella embarks on her most mind-bending adventure yet, traveling the various Threads of the Fabric to rally the Vampirellas of the multiple realities to join her in stopping the extermination of her self. First stop, an apocalyptic world transformed by a Chaos Plague. Will the Vampirella of this ravaged world heed our Vampirella's warning, or will she too fall to the savagery of Bloodwing?