With the flip of a switch, Project Rising Spirit has just infected every man, woman, and child in New York City with a designer "nanite virus," instantly transforming them into hard-coded killing machines.

Now, block by block, the citizens of America's greatest metropolis are falling prey to their own destructive urges...and Bloodshot is the only soldier tough enough to go head-to-head with the entire Big Apple gone bad! With the humanity of an entire city on the line, Bloodshot is waging a one-man assault on Manhattan to root out the source of this machine-made infection before it hits the heartland... but will bullets and brute force be enough to stop the spread of a pandemic deadlier than anything in human history?